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Comparative study of the sedative and antinociceptive effects of levomepromazine, azaperone and midazolam in laboratory animals Arq. Bras. Med. Vet. Zootec.
Mataqueiro,M.I.; D’Angelis,F.H.F.; De-Caroli-Neto,A.; Rossi,C.A.; Queiroz-Neto,A..
The sedative and antinociceptive effects of levomepromazine, azaperone and midazolam were studied in rats and mice using three behavior evaluation methods. Both exploratory behavior and spontaneous locomotor activity were significantly diminished in a spontaneous locomotor activity test in open field when using levomepromazine and azaperone. However, the azaperone effects were short lived in comparison to levomepromazine effects. Midazolam caused reduction in exploratory activity with no effect in spontaneous locomotion. When assessing the antinociceptive effect in the tail flick reflex latency test after infliction of a pain stimulus in rats, tested drugs did not show any antinociceptive effect. The drugs studied were able to abolish the writhing reflex...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sedation; Nociception; Levomepromazine; Azaperone; Midazolam.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000300009
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Effect of amitraz and xylazine on some physiological variables of horses Arq. Bras. Med. Vet. Zootec.
Queiroz-Neto,A.; Carregaro,A.B.; Zamur,G.; Harkins,J.D.; Tobin,T.; Mataqueiro,M.I.; Gonçalves,S.C..
The effect of the intravenous injection of amitraz (0.1mg/kg) to horses on cardiac activity, respiratory rate, intestinal motor activity, rectal temperature, sweating and masticating was evaluated and compared to the effect of intravenous administration of xylazine (1mg/kg, iv) on heart rate, respiratory rate and intestinal activity. Amitraz caused a significant decrease in heart activity, respiratory rate and intestinal movements, but these effects were not as pronounced as those caused by xylazine. Amitraz also caused a significant relaxation of the rectal smooth muscle, and an apparent increase in sweating and in the frequency of horses found masticating hay. Rectal temperature was not influenced by amitraz. The results indicated that amitraz, at the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Horse; Amitraz; Xylazine; Cardiac activity; Respiratory activity; Intestinal activity.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352000000100008
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Sedative and antinociceptive effects of romifidine and xylazine in Thoroughbred mares Arq. Bras. Med. Vet. Zootec.
Christovão,F.G.; Zamur,G.; Mataqueiro,M.I.; Queiroz-Neto,A..
The sedative and antinociceptive effects of romifidine (0.1mg/kg) and of xylazine (1.0mg/kg) on Thoroughbred mares were studied. Sedation was evaluated by quantifying spontaneous locomotor activity (SLA) and head height (HH) in animals placed in automated individual behaviour stalls. Antinociception was determined utilizing a heat irradiation lamp recording the latency time for the hoof withdrawal reflex (HWRL) and the latency time for the skin twitch reflex (STRL) in a randomised block design with 10 replicates. Comparison of the sedative effects of romifidine and of xylazine on SLA showed a faster effect for xylazine. Regarding the sedative effect of the substances based on HH, romifidine caused a longer-lasting effect. Romifidine caused an increase in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Horse; Romifidine; Xylazine; Antinociception; Sedation.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352006000600009
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